Selectively Desulphated Heparin Polymers
Prepared by site-selective, chemical methods to desulphate heparin at the aminosulphate (N-sulfate), C2 of uronic acid, C6 of glucosamine; in N-desulphated, re N-Acetylated heparin the “free” amino group has been acetylated. These products are useful for investigating the influence of specific sulphate groups on the conformation and binding properties of heparin.