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siTOOLs TECHNOTES

Technote 1: siRNA Off-target Effects - Causes, Extent & Impact

Learn about siRNA off-target effects. A reference-rich guide describing the mechanism by which siRNA off-targets are produced, the penetrance and extent of siRNA off-target effects, and the impact siRNA off-targets have on experimental research.

Download Technote 1: siRNA Off-target Effects - Causes, Extent & Impact

 

Technote 2: Ways to Reduce siRNA Off-target Effects

Understand current established techniques to reduce siRNA off-target effects, including the siPOOL approach. From siRNA concentration, chemical modification and siRNA design, this is a detailed technical overview of each approach and their pros and cons. We also provide a non-bias assessment of the effectiveness of each approach using data-driven bioinformatic analysis.

Download Technote 2: Ways to Reduce siRNA Off-target Effects

 

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