riboPOOLs (rRNA depletion)

riboPOOLs

riboPOOLs consist of complex pools of biotinylated DNA probes, specifically designed to hybridize and remove ribosomal RNAs (rRNA) from RNA samples. The riboPOOL rRNA depletion allows for an unbiased view of the species transcriptome and enables analysis of non-coding and non-polyadenylated RNAs.

Depletion of rRNAs with riboPOOLs can be easily incorporated into established laboratory protocols, and is compatible with many downstream applications, including short and long-read RNA sequencing and ribosome profiling (Ribo-Seq).

  • rRNA depletion for any species
  • Also available for highly degraded samples (FFPE)
  • Wide RNA input range (10 ng – 3 µg)
  • Optimized design of probe sequences for maximum target coverage and reliable rRNA removal

riboPOOL Probes and riboPOOL Kits

riboPOOLs are available in two formats: a complete kit including all necessary components for rRNA depletion, or as a probes-only option.  The probes-only format includes a protocol for buffer preparation and specifications for two pre-validated Streptavidin bead options.  Please note for the probe-only option the buffers and the Streptavidin beads must be sourced independently either through Galen Molecular or another supplier.

riboPOOL High-Input Kits riboPOOL Standard Kits riboPOOL Probes

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